منابع مشابه
Jgp_201611751 547..560
Cellular signaling relies on macromolecules to transduce stimuli information into conformational changes (Changeux and Edelstein, 2005). The mechanisms by which macromolecules accomplish this feat are often allosteric: a small stimulus applied at one area of the macromolecule regulates behavior at locations structurally distant from the active site of stimulation. A detailed and mechanistic und...
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Esculetin (6,7-dihydroxycoumarin) and its C-4 derivatives have multiple pharmacologic activities, but the poor metabolic stability of these catechols has severely restricted their application in the clinic. Glucuronidation plays important roles in catechols elimination, although thus far the effects of structural modifications on the metabolic selectivity and the catalytic efficacy of the human...
متن کاملDmd056358 546..560
Cholestasis, a hallmark feature of hepatobiliary disease, is characterized by the retention of biliary constituents. Some of these constituents, such as bile acids, inflict damage to hepatocytes and bile duct cells. This damage may lead to inflammation, fibrosis, cirrhosis, and eventually carcinogenesis, sequelae that aggravate the underlying disease and deteriorate clinical outcome. Canalicula...
متن کامل551-560-Peng GongR
Peroxisome-proliferator responsive element (PPRE) and nuclear factor-κB (NF-κB) response element have been found in the gene sequence of superoxide dismutase (SOD). This study determines the PPARs and NF-κB expression and SOD activity in damaged livers of rats with obstructive jaundice. Sprague-Dawley rats (n = 120) were randomly assigned into four groups: sham 7 days post-surgery (Sham 7), bil...
متن کاملJgp_201611751 547..560
Cellular signaling relies on macromolecules to transduce stimuli information into conformational changes (Changeux and Edelstein, 2005). The mechanisms by which macromolecules accomplish this feat are often allosteric: a small stimulus applied at one area of the macromolecule regulates behavior at locations structurally distant from the active site of stimulation. A detailed and mechanistic und...
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ژورنال
عنوان ژورنال: Pediatric Critical Care Medicine
سال: 2018
ISSN: 1529-7535
DOI: 10.1097/01.pcc.0000538017.23130.de